Luxury apartment-style hotel
I recently spent 3 nights at the Ascott Guangzhou on a business trip. Though the price is about the same as the other international hotels, you get a room that's more like an apartment than a hotel room. I was very impressed with the amenities (kitchen, sofa, TV, washer/dryer, ipod dock).
The breakfast selection was disappointing and the coffee was terrible, so after the first day I just made coffee and toast in my room's kitchen.
The staff were very helpful and professional, but not all of them speak English.
The Ascott is also on the same subway line as the airport, so it's very easy to get here by public transport. Just get off at Shipaiqiao station.